CHAMPS SITE
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Investigating the role of cytomegalovirus as a cause of stillbirths and child deaths in low and middle-income countries through postmortem minimally invasive tissue sampling
Multiple sitesClinical Infectious Disease2025Cite ShareVelaphi, S., Madewell, Z. J., Tippett-Barr, B., Blau, D. M., Rogena, E. A., Lala, S. G., Mahtab, S., Swart, P. J., Akelo, V., Onyango, D., Otieno, K., Rogena, E. A., Were, J. A., Bassat, Q., Carrilho, C., Mandomando, I., Torres-Fernandez, D., Varo, R., Luke, R., Moses, F., Nwajiobi-Princewill, P., Ogbuanu, I. U., Ojulong, J., Arifeen, S. E., Gurley, E. S., Assefa, N., Gedefa, L., Madrid, L., Scott, J. A. G., Wale, H., Juma, J., Keita, A. M., Kotloff, K. L., Sow, S. O., Tapia, M. D., Mutevedzi, P., Whitney, C. G., & Madhi, S. A. (2025). Investigating the role of cytomegalovirus as a cause of stillbirths and child deaths in low and middle-income countries through postmortem minimally invasive tissue sampling. Clinical Infectious Diseases, ciaf098. https://doi.org/10.1093/cid/ciaf098
Background There is paucity of information on the role of cytomegalovirus (CMV) infection as a cause of stillbirths or childhood deaths in low-and middle-income countries (LMICs). We investigated attribution of CMV-disease in the causal pathway to stillbirths and deaths in children <5 years of age in seven LMICs participating in…
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A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh
BangladeshBMC Microbiology2025Cite ShareAlam, M., Islam, M. S., Jahan, M. I., Deb, A. S., Rahman, A., Islam, Z., Chowdhury, A. I., Islam, K. M., Hossain, M. Z., Ahmed, D., Arifeen, S. E., Gurley, E. S., & Rahman, M. (2025). A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh. BMC Microbiology, 25, Article 61. https://doi.org/10.1186/s12866-024-03650-5
Background Listeria monocytogenes is a foodborne pathogen that can lead to severe pregnancy outcomes. This study reports the clinical and genomic characteristics of a Listeria-mediated stillbirth identified in January 2022 through the Child Health and Mortality Prevention Surveillance (CHAMPS) project in Bangladesh. The Lm-BD-CHAMPS-01 isolate was recovered from the blood and cerebrospinal fluid…
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Importance of postmortem anthropometric evaluation in defining the role of malnutrition as a cause of infant and child deaths in Sub-Saharan Africa and South Asia: a cohort study
Network-wide (all sites)BMJ Journal2025Cite ShareDas, P. M., Madewell, Z. J., Blau, D. M., Whitney, C.G., Ramakrishnan, U, Stein, A.D., Young, M.F, & Suchdev, P.S. (2025). Importance of postmortem anthropometric evaluation in defining the role of malnutrition as a cause of infant and child deaths in Sub-Saharan Africa and South Asia: a cohort study. BMJ Open, 15(e089874). https://doi.org/10.1136/bmjopen-2024-089874
Objectives: To evaluate how postmortem anthropometric malnutrition (PAM) measures align with expert panel attribution of malnutrition as a causal or significant condition in under-5 mortality (U5M). Design: Cohort study using data from the Child Health and Mortality Prevention Surveillance network, incorporating clinical records, postmortem anthropometrics, minimally invasive tissue sampling, clinical abstraction and…
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Post-mortem investigation of role of endemic human coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in the causal pathway to death amongst children under five in low- and middle-income countries: findings from the Child Health and Mortality Prevention Surveillance (CHAMPS)
Multiple sitesSSRN2025Cite ShareBaillie, V., Dangor, Z., Blau, D. M., Mahtab, S., du Toit, J., Assefa, N., Oundo, J., Teklemariam, Z., Scott, J. A. G., Ameh, S., Ogbuanu, I. U., Ojulong, J., Bunn, J., Kotloff, K. L., Sow, S. O., Tapia, M. D., Keita, A. M., Garrine, M., Mandomando, I., Varo, R., Xerinda, E., Rakislova, N., Alam, M., Arifeen, S., Gurley, E. S., Hossain, M. Z., Rahman, A., Akelo, V., Onyango, C., Onyango, D., Mutevedzi, P., Whitney, C. G., Bassat, Q., Madhi, S. A., & CHAMPS Consortium. (2024). Post-mortem investigation of role of endemic human coronaviruses in fatal acute respiratory infections in children in Kenya. SSRN. https://doi.org/10.2139/ssrn.5195408
Abstract Background: Endemic human coronaviruses (HCoV-229E, HKU1, NL63, and OC43) are common causes of mild or asymptomatic respiratory infections in children but are considered rare causes of death. Methods: We evaluated paediatric deaths from January 2017 to December 2022. A panel of experts determined the cause of death (CoD) by…
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Postmortem point-of care hemoglobin testing is feasible and potentially accurate among children in South Africa
South AfricaPLOS Global Public Health2025Cite Sharedu Toit, J., Wang, Y., Luo, H., Liu, L., Blau, D. M., Whitney, C. G., Werner, R., Bassat, Q., Storath, K., Makekeng, P., Dangor, Z., Mahdi, S. A., Wanga, V., & Suchdev, P. S. (2025). Postmortem point-of-care hemoglobin testing is feasible and potentially accurate among children in South Africa. PLOS Global Public Health, 5(2), e0003997. https://doi.org/10.1371/journal.pgph.0003997
Anemia is an important cause of child morbidity and mortality. Postmortem point-of-care hemoglobin testing is a potential method for assessing anemia at death, but its reliability has not been extensively studied. We aimed to assess the feasibility and validity of postmortem point-of-care hemoglobin assessment using HemoCue in the setting of…