CHAMPS Pathology

Accessing Pathology Images

Laboratory testing is critical for diagnosing infectious diseases when investigating infant or child deaths. CHAMPS uses pathologic evidence to accurately determine causes of death as well as for detection, surveillance, and research on emerging and reemerging pathogens that present additional risk to communities where we work.

CHAMPS is unique in that it employs the use of many different laboratories and pathologists across our network, all with different infrastructure and backgrounds, with the goals of determining causes of death and building pathology capacity in each country associated with our research.

Pathology slide images from CHAMPS cases are available upon request for research purposes. Users will be asked to sign a data use agreement.

These are images of tissue biopsies collected during minimally invasive tissue sampling procedures. Non-tissue and tissues undergo extensive laboratory testing including bacteria culture, HIV, tuberculosis, and malaria testing, and advanced diagnostics such as multiplex molecular testing for specific viral, bacterial, fungal, and parasitic pathogens. All tissue specimens are evaluated for histopathology and the slide images from this evaluation are also available in some cases.

Images are maintained by experts at the CHAMPS Program Office through NDPServe.

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Research in Action

CHAMPS Scientific Publications

Scientific Publications

January 4, 2022

Pathology and Telepathology Methods in the Child Health and Mortality Prevention Surveillance Network

This manuscript describes the Child Health and Mortality Prevention Surveillance (CHAMPS) network approach to pathologic evaluation of minimally invasive tissue sampling (MITS) specimens, including guidelines for histopathologic examination and further diagnostics with special stains, immunohistochemistry, and molecular testing, as performed at the CHAMPS Central Pathology Laboratory (CPL) at the Centers for Disease Control and Prevention, (…)

Conferences and Meetings

August 17, 2022

CHAMPS at ICEID 2022

CHAMPS was well-represented at the 2022 International Conference on Emerging Infectious Diseases (ICEID) in Atlanta, Georgia. The conference was hosted by the Centers for Disease Control and Prevention (CDC) in collaboration with the Task Force for Global Health, both longstanding partners of CHAMPS. CHAMPS researchers from across the network presented abstracts in oral and poster (…)

Scientific Publications

January 6, 2022

Causes of death in HIV-infected and HIV-uninfected children aged under-five years in western Kenya

This is a cross-sectional analysis of causes of death ascertained through minimally invasive tissue sampling (MITS) in the Kenya Child Health and Mortality Prevention Surveillance site. We included decedents aged 28 days to less than 5 years, whose death was reported within 36 h, underwent MITS, and had HIV test results and causes of death determined. (…)

Scientific Publications

December 7, 2021

Overview and Development of the Child Health and Mortality Prevention Surveillance Determination of Cause of Death (DeCoDe) Process and DeCoDe Diagnosis Standards

Mortality surveillance and cause of death data are instrumental in improving health, identifying diseases and conditions that cause a high burden of preventable deaths, and allocating resources to prevent these deaths. The Child Health and Mortality Prevention Surveillance (CHAMPS) network uses a standardized process to define, assign, and code causes of stillbirth and child death (…)

Scientific Publications

January 6, 2022

Postmortem investigations and identification of multiple causes of child deaths: An analysis of findings from the Child Health and Mortality Prevention Surveillance (CHAMPS) network

The current burden of >5 million deaths yearly is the focus of the Sustainable Development Goal (SDG) to end preventable deaths of newborns and children under 5 years old by 2030. To accelerate progression toward this goal, data are needed that accurately quantify the leading causes of death, so that interventions can target the common (…)