CHAMPS SITE
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A comparison of all-cause and HIV cause-specific mortality among children under 5 years of age before and during COVID-19 in Kenya, 2018–2022
KenyaPLOS Global Public Health2025Cite ShareGachau S, Akelo V, Cleveland A, Were J, Khagayi S, et al. (2025) A comparison of all-cause and HIV cause-specific mortality among children under 5 years of age before and during COVID-19 in Kenya, 2018–2022. PLOS Global Public Health 5(5): e0004338. https://doi.org/10.1371/journal.pgph.0004338
The impact of the COVID-19 pandemic on pediatric mortality, including measures to ensure continuity of HIV care, is not well described in Kenya. We evaluated causes of death (COD) among decedents under 5 years of age both before and during the COVID-19 pandemic in Kenya. We analyzed Child Health and…
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Adherence to Perinatal Asphyxia or Sepsis Management Guidelines in Low- and Middle-Income Countries
Multiple sitesJAMA Network Open2025Cite ShareRahman ARay MMadewell ZJ, et al. Adherence to Perinatal Asphyxia or Sepsis Management Guidelines in Low- and Middle-Income Countries. JAMA Netw Open. 2025;8(5):e2510790. doi:10.1001/jamanetworkopen.2025.10790
Key Points Question Do neonates who die of perinatal asphyxia or sepsis in low- and middle-income countries receive guideline-adherent clinical care? Findings In this cross-sectional study of 1194 neonates who died, less than 5% of those who died with perinatal asphyxia received all recommended clinical care, and 61% of those who died…
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Importance of postmortem anthropometric evaluation in defining the role of malnutrition as a cause of infant and child deaths in Sub-Saharan Africa and South Asia: a cohort study
Network-wide (all sites)BMJ Journal2025Cite ShareDas, P. M., Madewell, Z. J., Blau, D. M., Whitney, C.G., Ramakrishnan, U, Stein, A.D., Young, M.F, & Suchdev, P.S. (2025). Importance of postmortem anthropometric evaluation in defining the role of malnutrition as a cause of infant and child deaths in Sub-Saharan Africa and South Asia: a cohort study. BMJ Open, 15(e089874). https://doi.org/10.1136/bmjopen-2024-089874
Objectives: To evaluate how postmortem anthropometric malnutrition (PAM) measures align with expert panel attribution of malnutrition as a causal or significant condition in under-5 mortality (U5M). Design: Cohort study using data from the Child Health and Mortality Prevention Surveillance network, incorporating clinical records, postmortem anthropometrics, minimally invasive tissue sampling, clinical abstraction and…
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Post-mortem investigation of role of endemic human coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in the causal pathway to death amongst children under five in low- and middle-income countries: findings from the Child Health and Mortality Prevention Surveillance (CHAMPS)
Multiple sitesSSRN2025Cite ShareBaillie, V., Dangor, Z., Blau, D. M., Mahtab, S., du Toit, J., Assefa, N., Oundo, J., Teklemariam, Z., Scott, J. A. G., Ameh, S., Ogbuanu, I. U., Ojulong, J., Bunn, J., Kotloff, K. L., Sow, S. O., Tapia, M. D., Keita, A. M., Garrine, M., Mandomando, I., Varo, R., Xerinda, E., Rakislova, N., Alam, M., Arifeen, S., Gurley, E. S., Hossain, M. Z., Rahman, A., Akelo, V., Onyango, C., Onyango, D., Mutevedzi, P., Whitney, C. G., Bassat, Q., Madhi, S. A., & CHAMPS Consortium. (2024). Post-mortem investigation of role of endemic human coronaviruses in fatal acute respiratory infections in children in Kenya. SSRN. https://doi.org/10.2139/ssrn.5195408
Abstract Background: Endemic human coronaviruses (HCoV-229E, HKU1, NL63, and OC43) are common causes of mild or asymptomatic respiratory infections in children but are considered rare causes of death. Methods: We evaluated paediatric deaths from January 2017 to December 2022. A panel of experts determined the cause of death (CoD) by…
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Postmortem point-of care hemoglobin testing is feasible and potentially accurate among children in South Africa
South AfricaPLOS Global Public Health2025Cite Sharedu Toit, J., Wang, Y., Luo, H., Liu, L., Blau, D. M., Whitney, C. G., Werner, R., Bassat, Q., Storath, K., Makekeng, P., Dangor, Z., Mahdi, S. A., Wanga, V., & Suchdev, P. S. (2025). Postmortem point-of-care hemoglobin testing is feasible and potentially accurate among children in South Africa. PLOS Global Public Health, 5(2), e0003997. https://doi.org/10.1371/journal.pgph.0003997
Anemia is an important cause of child morbidity and mortality. Postmortem point-of-care hemoglobin testing is a potential method for assessing anemia at death, but its reliability has not been extensively studied. We aimed to assess the feasibility and validity of postmortem point-of-care hemoglobin assessment using HemoCue in the setting of…